CD6 and CD5

Data Source:
HPRD (in vitro, in vivo)

		CD6	CD5
Description		CD6 molecule	CD5 molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Integral Component Of Plasma Membrane External Side Of Plasma Membrane Intrinsic Component Of Plasma Membrane T Cell Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Lipopolysaccharide Binding Scavenger Receptor Activity Protein Binding Identical Protein Binding Lipoteichoic Acid Binding	Scavenger Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Acute Inflammatory Response To Antigenic Stimulus Endocytosis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Endocytosis Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 24076602 21833088) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		5 interacting genes: ALCAM CD5 GYG1 NFE2L1 SDCBP	21 interacting genes: CAMK2D CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70
Entrez ID		923	921
HPRD ID		01724	01078
Ensembl ID		ENSG00000013725	ENSG00000110448
Uniprot IDs		P30203 Q6AZ88 Q8N4Q7	P06127
PDB IDs		5A2E	2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?
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