CD6 and ALCAM

Data Source:
HPRD (in vitro, in vivo)

		CD6	ALCAM
Description		CD6 molecule	activated leukocyte cell adhesion molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Integral Component Of Plasma Membrane External Side Of Plasma Membrane Intrinsic Component Of Plasma Membrane T Cell Receptor Complex	Immunological Synapse Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Axon Dendrite Intrinsic Component Of Plasma Membrane T Cell Receptor Complex Neuronal Cell Body Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Scavenger Receptor Activity Protein Binding Identical Protein Binding Lipoteichoic Acid Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Acute Inflammatory Response To Antigenic Stimulus Endocytosis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Adaptive Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Motor Neuron Axon Guidance Retinal Ganglion Cell Axon Guidance Axon Extension Involved In Axon Guidance Neuron Projection Extension
Pathways			L1CAM interactions
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Adult body size ( 32376654) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Breast cancer ( 31757997) Chronotype ( 30696823) Cortical surface area (visual PC2) ( 32198502) Erectile dysfunction in type 1 diabetes ( 22704111) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 29617998) Irritable mood ( 29500382) Metabolite levels ( 23823483) Ovarian disease with few adhesions ( 28333195) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Visceral fat ( 30942860)
Interacting Genes		5 interacting genes: ALCAM CD5 GYG1 NFE2L1 SDCBP	3 interacting genes: ART3 CD6 EGFR
Entrez ID		923	214
HPRD ID		01724	03389
Ensembl ID		ENSG00000013725	ENSG00000170017
Uniprot IDs		P30203 Q6AZ88 Q8N4Q7	B3KNN9 Q13740
PDB IDs		5A2E	1KJC 5A2F
Enriched GO Terms of Interacting Partners?
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