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ZW10 and PIAS4
Data Source:
BioGRID
(pull down)
ZW10
PIAS4
Description
zw10 kinetochore protein
protein inhibitor of activated STAT 4
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Spindle Pole
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Kinetochore Microtubule
Cytosol
Membrane
Dsl1/NZR Complex
RZZ Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
PML Body
Transferase Complex
Molecular Function
Protein Binding
Centromeric DNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Biological Process
Mitotic Sister Chromatid Segregation
Establishment Of Mitotic Spindle Orientation
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Golgi Organization
Mitotic Metaphase Plate Congression
Mitotic Spindle Assembly Checkpoint
Regulation Of Exit From Mitosis
Protein Transport
Protein Localization To Kinetochore
Cell Division
Meiotic Cell Cycle
Protein-containing Complex Assembly
Signal Transduction Involved In Mitotic Cell Cycle Checkpoint
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Sumoylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Sumoylation
Vitamin D Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Keratinocyte Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Vitamin D (calciferol) metabolism
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Parental longevity (father's attained age) (
29227965
)
Chronic lymphocytic leukemia (
28165464
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
7 interacting genes:
APP
DCTN2
PIAS4
PTF1A
RINT1
ZWILCH
ZWINT
85 interacting genes:
ACTN1
ALDOA
AR
AREL1
BARD1
BRCA1
BTAF1
CALCOCO2
CEBPD
CHD3
CLK1
COIL
ESRRA
FTH1
GADD45G
HDAC1
HDAC2
HNF4A
HNRNPUL1
HTT
IL15RA
IMMT
IMPDH2
IRF3
IRF7
KNTC1
KPNB1
KRT18
LAMP2
LCE1D
LEF1
LRIF1
MAGEH1
MAP1LC3A
MDC1
MPRIP
NEFL
NR4A2
OAZ1
OPTN
PARP1
PDE4A
PDE4D
PDE4DIP
PHF11
PHGDH
PIAS1
PIAS2
PLAG1
PRKCZ
PRPF40A
PTN
RIF1
SATB1
SERBP1
SERPINA5
SETDB1
SH3GL3
SKIL
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SNAI2
SNIP1
SUMO1
SUMO2
SUMO3
TADA3
TCERG1
TICAM1
TOP2A
TP53
TRIM27
TRIM32
TRIM38
UBE2I
UBE2K
VHL
VIM
ZBTB34
ZHX1
ZNF512B
ZW10
Entrez ID
9183
51588
HPRD ID
04902
06910
Ensembl ID
ENSG00000086827
ENSG00000105229
Uniprot IDs
O43264
B3KMR4
Q8N2W9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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