PIAS4 and PDE4A

Data Source:
BioGRID (enzymatic study)

		PIAS4	PDE4A
Description		protein inhibitor of activated STAT 4	phosphodiesterase 4A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling
Pathways		Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)
Interacting Genes		85 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM ZBTB34 ZHX1 ZNF512B ZW10	6 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4
Entrez ID		51588	5141
HPRD ID		06910	02527
Ensembl ID		ENSG00000105229	ENSG00000065989
Uniprot IDs		B3KMR4 Q8N2W9	P27815
PDB IDs			2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?
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