ZW10 and DCTN2

Data Source:
HPRD (two hybrid)

		ZW10	DCTN2
Description		zw10 kinetochore protein	dynactin subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Kinetochore Microtubule Cytosol Membrane Dsl1/NZR Complex RZZ Complex	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Centromeric DNA Binding	Motor Activity Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Protein Transport Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Protein-containing Complex Assembly Signal Transduction Involved In Mitotic Cell Cycle Checkpoint	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Mitotic Metaphase Plate Congression Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Parental longevity (father's attained age) ( 29227965)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: APP DCTN2 PIAS4 PTF1A RINT1 ZWILCH ZWINT	35 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 BORCS6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 PAFAH1B1 RABGEF1 RINT1 RPGR SMARCD1 TXLNB USHBP1 ZW10
Entrez ID		9183	10540
HPRD ID		04902	09568
Ensembl ID		ENSG00000086827	ENSG00000175203
Uniprot IDs		O43264	A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58
PDB IDs
Enriched GO Terms of Interacting Partners?
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