DCTN2 and COG3

Data Source:
BioGRID (two hybrid)

		DCTN2	COG3
Description		dynactin subunit 2	component of oligomeric golgi complex 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Golgi Membrane Golgi Apparatus Cis-Golgi Network Cytosol Plasma Membrane Golgi Transport Complex Golgi Cisterna Membrane Trans-Golgi Network Membrane
	Molecular Function	Motor Activity Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Mitotic Metaphase Plate Congression Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking	Protein Glycosylation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Localization To Organelle Protein Stabilization
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873)
Interacting Genes		35 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 BORCS6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 PAFAH1B1 RABGEF1 RINT1 RPGR SMARCD1 TXLNB USHBP1 ZW10	11 interacting genes: ABI2 CINP COG1 COG2 DCTN2 KIFC3 NUP58 SPG21 TRIM2 TSHZ2 ZDHHC17
Entrez ID		10540	83548
HPRD ID		09568	08443
Ensembl ID		ENSG00000175203	ENSG00000136152
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	Q96JB2
PDB IDs
Enriched GO Terms of Interacting Partners?
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