DERL3 and MELTF

Data Source:
HPRD (in vivo)

		DERL3	MELTF
Description		derlin 3	melanotransferrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Endoplasmic Reticulum Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Recycling Endosome Extracellular Exosome
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Iron Ion Binding Protein Binding
	Biological Process	Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Malaria ( 31844061)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	10 interacting genes: CYSRT1 DERL1 DERL2 DERL3 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA
Entrez ID		91319	4241
HPRD ID		13139	01122
Ensembl ID		ENSG00000099958	ENSG00000163975
Uniprot IDs		Q96Q80	P08582 Q53XS6
PDB IDs
Enriched GO Terms of Interacting Partners?
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