DERL3 and GNLY

Data Source:
BioGRID (two hybrid)

		DERL3	GNLY
Description		derlin 3	granulysin
Image		No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Endoplasmic Reticulum Membrane	Extracellular Region Extracellular Space Cytolytic Granule Phagocytic Vesicle Lumen
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Cellular Defense Response Antimicrobial Humoral Response Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	Antimicrobial peptides
Drugs			3-(N-morpholino)propanesulfonic acid
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Blood protein levels ( 29875488 28240269)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	4 interacting genes: APP BCL2L1 DERL3 FBXO7
Entrez ID		91319	10578
HPRD ID		13139	01788
Ensembl ID		ENSG00000099958	ENSG00000115523
Uniprot IDs		Q96Q80	B4E3H9 P22749
PDB IDs			1L9L
Enriched GO Terms of Interacting Partners?
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