ZNF251 and MDC1

Data Source:
BioGRID (two hybrid)

		ZNF251	MDC1
Description		zinc finger protein 251	mediator of DNA damage checkpoint 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways			SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		11 interacting genes: FEZ1 FEZ2 FHL5 KRTAP10-9 MDC1 MX1 PAXIP1 SMAD1 SPTBN1 TRIM41 TSC22D2	40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		90987	9656
HPRD ID		19696	16252
Ensembl ID		ENSG00000198169	ENSG00000137337
Uniprot IDs		Q9BRH9	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs			2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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