USP15 and FHL1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP15	FHL1
Description		ubiquitin specific peptidase 15	four and a half LIM domains 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity	Molecular_function Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway	Regulation Of Membrane Depolarization Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases			X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBE2S UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	32 interacting genes: AKAP12 CBX4 CDC25C CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40
Entrez ID		9958	2273
HPRD ID		05293	02157
Ensembl ID		ENSG00000135655	ENSG00000022267
Uniprot IDs		Q9Y4E8	B7Z9A1 Q13642 Q5JXI2
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1	1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?
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