SEC11C and UBE2J1

Data Source:
BioGRID (two hybrid)

		SEC11C	UBE2J1
Description		SEC11 homolog C, signal peptidase complex subunit	ubiquitin conjugating enzyme E2 J1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Signal Peptide Processing	Protein Polyubiquitination Spermatid Development Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA	48 interacting genes: AQP2 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DERL1 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MFSD14B MFSD3 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC
Entrez ID		90701	51465
HPRD ID		15310	15599
Ensembl ID		ENSG00000166562	ENSG00000198833
Uniprot IDs		K7EJQ7 Q9BY50	Q9Y385
PDB IDs
Enriched GO Terms of Interacting Partners?
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