UBE2J1 and DERL1

Data Source:
BioGRID (two hybrid)

		UBE2J1	DERL1
Description		ubiquitin conjugating enzyme E2 J1	derlin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Integral Component Of Membrane	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Polyubiquitination Spermatid Development Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		48 interacting genes: AQP2 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DERL1 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MFSD14B MFSD3 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC	33 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBE2J1 UBXN6 VCP
Entrez ID		51465	79139
HPRD ID		15599	12302
Ensembl ID		ENSG00000198833	ENSG00000136986
Uniprot IDs		Q9Y385	A0A024R9G3 E5RGY0 Q9BUN8
PDB IDs			5GLF
Enriched GO Terms of Interacting Partners?
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