UBE2J1 and AQP2

Data Source:
BioGRID (two hybrid)

		UBE2J1	AQP2
Description		ubiquitin conjugating enzyme E2 J1	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Integral Component Of Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Protein Polyubiquitination Spermatid Development Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		48 interacting genes: AQP2 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DERL1 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MFSD14B MFSD3 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC	60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		51465	359
HPRD ID		15599	00141
Ensembl ID		ENSG00000198833	ENSG00000167580
Uniprot IDs		Q9Y385	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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