TP63 and UBASH3A

Data Source:
BioGRID (two hybrid)

		TP63	UBASH3A
Description		tumor protein p63	ubiquitin associated and SH3 domain containing A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Dendrite Protein-containing Complex	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Establishment Of Planar Polarity Epithelial Cell Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Cell Aging Cell Population Proliferation Proximal/distal Pattern Formation Multicellular Organism Aging Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skin Morphogenesis Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Female Genitalia Morphogenesis Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases		Limb-mammary syndrome ADULT syndrome Split-hand/foot malformation (SHFM) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Chlamydia trachomatis PorB antibody levels ( 33204752) Circulating leptin levels in high cardiovascular risk ( 31766143) Cleft lip with or without cleft palate ( 28054174) Cutaneous squamous cell carcinoma ( 32041948) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 28604730 22797724 20871597) Lung cancer ( 28604730 21725308 23143601 24880342) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Orofacial clefts ( 28054174) Pancreatic cancer ( 29422604 26098869) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)	Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781) Vitiligo ( 20410501 27723757)
Interacting Genes		41 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITCH ITIH4 KAT2B MCRS1 MDM4 NIPSNAP3A ORM1 PELI1 PELI2 PIN1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 TP53 TP73 UBASH3A UBE2I WT1	89 interacting genes: ARRDC1 ARRDC3 BCAR3 C9orf24 CBLB CBS CCDC33 CD3E COPS9 DAZAP2 DDIT4L DISC1 DLGAP4 DNM2 DTX3 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 N4BP3 NSMF PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SNRNP48 SOS1 SPRY1 SPRY2 STX11 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B WAS WASL WBP11 ZBTB42 ZC2HC1C ZNF219 ZNF474 ZRANB1
Entrez ID		8626	53347
HPRD ID		04469	06904
Ensembl ID		ENSG00000073282	ENSG00000160185
Uniprot IDs		A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4	P57075
PDB IDs		1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN 6RU6 6RU7 6RU8	2CRN 5WDI
Enriched GO Terms of Interacting Partners?
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