EIF2S2 and EIF5

Data Source:
HPRD (in vivo, in vitro)

		EIF2S2	EIF5
Description		eukaryotic translation initiation factor 2 subunit beta	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		23 interacting genes: APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1
Entrez ID		8894	1983
HPRD ID		04882	03417
Ensembl ID		ENSG00000125977	ENSG00000100664
Uniprot IDs		P20042 Q6IBR8	A0A024R6Q1 P55010
PDB IDs		6K71 6K72 6YBV 6ZMW 6ZP4 7A09	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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