EIF5 and EIF3G

Data Source:
HPRD (in vivo)

		EIF5	EIF3G
Description		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 3 subunit G
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	28 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14
Entrez ID		1983	8666
HPRD ID		03417	04886
Ensembl ID		ENSG00000100664	ENSG00000130811
Uniprot IDs		A0A024R6Q1 P55010	O75821
PDB IDs		2E9H 2G2K 2IU1	2CQ0 2MJC 5K0Y 6YBS 6ZMW
Enriched GO Terms of Interacting Partners?
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