EIF5 and DUSP12

Data Source:
BioGRID (two hybrid)

		EIF5	DUSP12
Description		eukaryotic translation initiation factor 5	dual specificity phosphatase 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Phosphatase Activity Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity	Cellular Protein Modification Process Protein Dephosphorylation Dephosphorylation Positive Regulation Of Glucokinase Activity Peptidyl-tyrosine Dephosphorylation
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	Albumin-globulin ratio ( 29403010) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Non-albumin protein levels ( 29403010)
Interacting Genes		16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	13 interacting genes: APP CALCOCO2 CCNH CEP126 EIF5 HSPB8 M6PR MBD6 NR1H2 PPP2R3B PTN RABAC1 USO1
Entrez ID		1983	11266
HPRD ID		03417	05323
Ensembl ID		ENSG00000100664	ENSG00000081721
Uniprot IDs		A0A024R6Q1 P55010	Q9UNI6
PDB IDs		2E9H 2G2K 2IU1	4JNB 4KI9
Enriched GO Terms of Interacting Partners?
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