EIF2S2 and EIF2B4

Data Source:
HPRD (in vitro)

		EIF2S2	EIF2B4
Description		eukaryotic translation initiation factor 2 subunit beta	eukaryotic translation initiation factor 2B subunit delta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport	Ovarian Follicle Development Translational Initiation Regulation Of Translation Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)	Non-oily fish consumption ( 32066663)
Interacting Genes		23 interacting genes: APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	3 interacting genes: EIF2B2 EIF2S1 EIF2S2
Entrez ID		8894	8890
HPRD ID		04882	09459
Ensembl ID		ENSG00000125977	ENSG00000115211
Uniprot IDs		P20042 Q6IBR8	B4DUP5 E7ERK9 F8W8L6 Q71US4 Q9HBP7 Q9UI10
PDB IDs		6K71 6K72 6YBV 6ZMW 6ZP4 7A09	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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