TMEM11 and NDUFS3

Data Source:
BioGRID (two hybrid)

		TMEM11	NDUFS3
Description		transmembrane protein 11	NADH:ubiquinone oxidoreductase core subunit S3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Integral Component Of Plasma Membrane Integral Component Of Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane
	Molecular Function	Molecular_function Protein Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	Mitochondrion Organization Inner Mitochondrial Membrane Organization	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cristae formation	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483)	Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		53 interacting genes: ARL13B BDKRB2 BIK BNIP3 BNIP3L CCDC70 CCR4 CD79A CLDN7 CLN8 CREB3L1 CYB561 CYB5D2 DRD2 EBP ELOVL4 FAM174A FAM209A FAM210B FATE1 FFAR2 GJB4 GORAB KASH5 LEPROTL1 LMNA MRM1 MSMO1 MTIF3 MUC1 NDUFS3 OTX2 PDZK1IP1 PEX12 RETREG3 RIC3 RNASEH1 SCMH1 SGCB SLC10A6 SLC30A8 SUSD3 SUV39H1 TEX29 TMEM106C TMEM14B TMEM205 TMEM237 TMEM88 TMIE TMPRSS2 TNFSF14 YIPF6	4 interacting genes: GZMA NDUFA5 RASL10B TMEM11
Entrez ID		8834	4722
HPRD ID		12680	10355
Ensembl ID		ENSG00000178307	ENSG00000213619
Uniprot IDs		P17152	O75489
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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