PRKRA and PLEKHA3

Data Source:
BioGRID (biochemical)

		PRKRA	PLEKHA3
Description		protein activator of interferon induced protein kinase EIF2AK2	pleckstrin homology domain containing A3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Golgi Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	Protein Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Phosphatidylinositol Biosynthetic Process Biological_process Ceramide Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Synthesis of PIPs at the plasma membrane
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 LNX1 LYAR NKRF PIAS2 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746	8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B
Entrez ID		8575	65977
HPRD ID		04573	09688
Ensembl ID		ENSG00000180228	ENSG00000116095
Uniprot IDs		B4DJC7 O75569	Q9HB20
PDB IDs		2DIX	2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?
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