PRKRA and ZFP28

Data Source:
BioGRID (two hybrid)

		PRKRA	ZFP28
Description		protein activator of interferon induced protein kinase EIF2AK2	ZFP28 zinc finger protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Generic Transcription Pathway
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Apolipoprotein B levels ( 32203549)
Interacting Genes		28 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 LNX1 LYAR NKRF PIAS2 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746	5 interacting genes: C8orf33 HMOX2 KDM1A PPP2CB PRKRA
Entrez ID		8575	140612
HPRD ID		04573	15725
Ensembl ID		ENSG00000180228	ENSG00000196867
Uniprot IDs		B4DJC7 O75569	Q8NHY6
PDB IDs		2DIX	2EM2 2EM3 2EM4 2EMJ 2EMK 2EML 2EN9 2ENH 2EOH 2EP0 2EPX 2EPZ 2YTM
Enriched GO Terms of Interacting Partners?
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