TRIM5 and USP21

Data Source:
BioGRID (two hybrid)

		TRIM5	USP21
Description		tripartite motif containing 5	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Omegasome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Activation Of Innate Immune Response Autophagy Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010 32888494) Serum alkaline phosphatase levels ( 29403010) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		46 interacting genes: BTBD1 BTBD2 EHHADH EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		85363	27005
HPRD ID		07004	05291
Ensembl ID		ENSG00000132256	ENSG00000143258
Uniprot IDs		Q9C035	Q9UK80
PDB IDs		2ECV 2YRG	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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