TRIM5 and BTBD1

Data Source:
HPRD (in vitro)

		TRIM5	BTBD1
Description		tripartite motif containing 5	BTB domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Omegasome	P-body Nucleoplasm Cytosol Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Polyubiquitination Activation Of Innate Immune Response Autophagy Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Muscle Organ Development Protein Ubiquitination Neurogenesis Regulation Of Protein Binding Post-translational Protein Modification
Pathways		Interferon gamma signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010 32888494) Serum alkaline phosphatase levels ( 29403010) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163) Kawasaki disease ( 21326860)
Interacting Genes		46 interacting genes: BTBD1 BTBD2 EHHADH EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	10 interacting genes: CUL3 LNX1 MPP3 MTNR1B NTAQ1 PSMD5 RNF4 TOP1 TRIM5 TULP3
Entrez ID		85363	53339
HPRD ID		07004	12251
Ensembl ID		ENSG00000132256	ENSG00000064726
Uniprot IDs		Q9C035	A0A024R224 Q9H0C5
PDB IDs		2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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