TRIM5 and TRIM6

Data Source:
HPRD (two hybrid)

		TRIM5	TRIM6
Description		tripartite motif containing 5	tripartite motif containing 6
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Omegasome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity Protein Tyrosine Kinase Binding
	Biological Process	Protein Polyubiquitination Activation Of Innate Immune Response Autophagy Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Viral Process Protein Ubiquitination Response To Lipopolysaccharide Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Stem Cell Differentiation
Pathways		Interferon gamma signaling	Interferon gamma signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010 32888494) Serum alkaline phosphatase levels ( 29403010) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Malaria ( 31844061)
Interacting Genes		46 interacting genes: BTBD1 BTBD2 EHHADH EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	4 interacting genes: LGALS3 LGALS8 MYC TRIM5
Entrez ID		85363	117854
HPRD ID		07004	12123
Ensembl ID		ENSG00000132256	ENSG00000121236
Uniprot IDs		Q9C035	Q9C030
PDB IDs		2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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