PPFIA1 and CAST

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PPFIA1	CAST
Description		PTPRF interacting protein alpha 1	calpastatin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Calcium Artenimol
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 29381148 26426971) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DNAJC5 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		8500	831
HPRD ID		11451	00233
Ensembl ID		ENSG00000131626	ENSG00000153113
Uniprot IDs		B3KVS8 Q13136	B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs		1N7F
Enriched GO Terms of Interacting Partners?
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