CAST and HTRA1

Data Source:
HPRD (two hybrid)

		CAST	HTRA1
Description		calpastatin	HtrA serine peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Placenta Development Proteolysis Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Degradation of the extracellular matrix
Drugs		Calcium Artenimol
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 29381148 26426971) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778 33020668) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		831	5654
HPRD ID		00233	03725
Ensembl ID		ENSG00000153113	ENSG00000166033
Uniprot IDs		B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9	Q92743
PDB IDs			2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?
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