PPFIA1 and ERC2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		PPFIA1	ERC2
Description		PTPRF interacting protein alpha 1	ELKS/RAB6-interacting/CAST family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Cytoskeleton Growth Cone Presynaptic Membrane Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Neuromuscular Synaptic Transmission Synaptic Vesicle Priming Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Interacting Genes		31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DNAJC5 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG	8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		8500	26059
HPRD ID		11451	10810
Ensembl ID		ENSG00000131626	ENSG00000187672
Uniprot IDs		B3KVS8 Q13136	O15083
PDB IDs		1N7F
Enriched GO Terms of Interacting Partners?
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