ERC2 and PPFIA2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		ERC2	PPFIA2
Description		ELKS/RAB6-interacting/CAST family member 2	PTPRF interacting protein alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Growth Cone Presynaptic Membrane Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Cell Surface Axon Dendritic Spine Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding Structural Constituent Of Presynapse
	Biological Process	Neuromuscular Synaptic Transmission Synaptic Vesicle Priming Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure	Cell-matrix Adhesion Neurotransmitter Secretion Glutamate Secretion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	Age-related cataracts (age at onset) ( 25352737) Alcohol dependence ( 26365420) Delirium ( 29631748) Lean body mass ( 28552196) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Schizophrenia ( 22885689)
Interacting Genes		8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	13 interacting genes: CAST CDC5L ERC2 GIT1 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS
Entrez ID		26059	8499
HPRD ID		10810	04392
Ensembl ID		ENSG00000187672	ENSG00000139220
Uniprot IDs		O15083	B7Z7Y5 G3V200 H0YHK3 O75334 Q4LE62
PDB IDs			3TAC 3TAD 6IUH
Enriched GO Terms of Interacting Partners?
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