FAM136A and DPY30

Data Source:
BioGRID (two hybrid)

		FAM136A	DPY30
Description		family with sequence similarity 136 member A	dpy-30 histone methyltransferase complex regulatory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process		Chromatin Silencing At Telomere Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Response to citalopram or escitalopram in depression ( 27622933) Total cholesterol levels ( 30275531)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		11 interacting genes: ANKRD11 DPY30 MAGEB4 MBD3 MEIS2 NTAQ1 P4HA3 PSMB1 RUNX1T1 SMARCD1 TTC19	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		84908	84661
HPRD ID		07866	17434
Ensembl ID		ENSG00000035141	ENSG00000162961
Uniprot IDs		B0AZT6 E7EQY1 Q96C01	B4DIS3 Q9C005
PDB IDs			3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
Enriched GO Terms of Interacting Partners?
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