DPY30 and AK8

Data Source:
BioGRID (two hybrid)

		DPY30	AK8
Description		dpy-30 histone methyltransferase complex regulatory subunit	adenylate kinase 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Cytoplasm Cytosol Axoneme Sperm Flagellum
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Adenylate Kinase Activity Cytidylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding
	Biological Process	Chromatin Silencing At Telomere Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation	Nucleoside Diphosphate Phosphorylation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Ventricular System Development Nucleoside Monophosphate Phosphorylation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Interconversion of nucleotide di- and triphosphates
Drugs			Bis(Adenosine)-5'-Pentaphosphate
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Obesity-related traits ( 23251661)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	16 interacting genes: ALKBH3 CCDC102B CDK18 CNTF DPY30 FBXO7 HAUS1 MAP3K7CL MCM7 MID1IP1 PRMT6 RBM39 SMG9 SYT17 UBE2Z ZMAT2
Entrez ID		84661	158067
HPRD ID		17434	12991
Ensembl ID		ENSG00000162961	ENSG00000165695
Uniprot IDs		B4DIS3 Q9C005	Q96MA6
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
Enriched GO Terms of Interacting Partners?
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