ING5 and NAV2

Data Source:
HPRD (two hybrid)

		ING5	NAV2
Description		inhibitor of growth family member 5	neuron navigator 2
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome MOZ/MORF Histone Acetyltransferase Complex	Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding Methylated Histone Binding Metal Ion Binding	Protein Binding ATP Binding 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication Protein Acetylation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Histone H4 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway	Nervous System Development Neurogenesis DNA Duplex Unwinding
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet distribution width ( 32888494)	Adverse response to drug ( 30420678) Atrial fibrillation ( 30061737 29892015) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) Brain morphology (MOSTest) ( 32665545) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General cognitive ability ( 29844566) Hepatitis ( 25705159) Low susceptibility to hepatitis C infection ( 31206233) Macular thickness ( 30535121) Monobrow ( 27182965) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Smoking initiation (ever regular vs never regular) ( 30679032) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Waist circumference ( 28552196)
Interacting Genes		47 interacting genes: APC APLP1 ARFIP2 BARD1 BEX3 BRPF1 C3orf62 CBY2 CCDC33 CCHCR1 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH GGA1 GRIPAP1 HAP1 HGS HTT ICA1 IKZF3 JADE2 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 ODF2 PCM1 PRMT5 RCOR3 SMARCE1 SUOX TADA3 TAF1D THAP6 TP53 TRIML2 VIM WASF1	12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS
Entrez ID		84289	89797
HPRD ID		16348	07385
Ensembl ID		ENSG00000168395	ENSG00000166833
Uniprot IDs		A0A1B0GW41 Q8WYH8	A7E2D6 Q8IVL1
PDB IDs		3C6W 5ME8 5MTO	2YRN
Enriched GO Terms of Interacting Partners?
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