ASCC2 and SASH1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ASCC2	SASH1
Description		activating signal cointegrator 1 complex subunit 2	SAM and SH3 domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Activating Signal Cointegrator 1 Complex	Cytoplasm Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Binding	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	DNA Dealkylation Involved In DNA Repair Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination
Pathways		ALKBH3 mediated reversal of alkylation damage
Drugs
Diseases
GWAS		Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)	Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		84164	23328
HPRD ID		16515	06408
Ensembl ID		ENSG00000100325	ENSG00000111961
Uniprot IDs		A0A024R1E1 A0A024R1F9 Q9H1I8	O94885
PDB IDs		2DI0 6YXQ	2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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