USP9X and BCL9

Data Source:
BioGRID (pull down)

		USP9X	BCL9
Description		ubiquitin specific peptidase 9 X-linked	BCL9 transcription coactivator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Nucleoplasm Cis-Golgi Network Beta-catenin-TCF Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Protein Targeting To Peroxisome Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Cell Migration Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Regulation Of Circadian Rhythm Cellular Protein Metabolic Process Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Migraine ( 27322543)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)
Interacting Genes		25 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RNF115 SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	4 interacting genes: CTNNB1 PYGO1 PYGO2 USP9X
Entrez ID		8239	607
HPRD ID		02091	04000
Ensembl ID		ENSG00000124486	ENSG00000116128
Uniprot IDs		Q6P468 Q86X58 Q93008	A0A024QYY4 O00512 Q1JQ81
PDB IDs		5VBD 5WCH	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9
Enriched GO Terms of Interacting Partners?
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