BCL9 and PYGO1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		BCL9	PYGO1
Description		BCL9 transcription coactivator	pygopus family PHD finger 1
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GO Annotations	Cellular Component	Nucleoplasm Cis-Golgi Network Beta-catenin-TCF Complex	Nucleoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding	Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CTNNB1 PYGO1 PYGO2 USP9X	6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1
Entrez ID		607	26108
HPRD ID		04000	06064
Ensembl ID		ENSG00000116128	ENSG00000171016
Uniprot IDs		A0A024QYY4 O00512 Q1JQ81	Q9Y3Y4
PDB IDs		2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9	2VP7 2VPB 2VPD 2VPE 2VPG
Enriched GO Terms of Interacting Partners?
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