USP9X and TDRD3

Data Source:
BioGRID (pull down, pull down)

		USP9X	TDRD3
Description		ubiquitin specific peptidase 9 X-linked	tudor domain containing 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Nucleus Nucleoplasm Golgi Apparatus Cytosol Exon-exon Junction Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Protein Targeting To Peroxisome Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Cell Migration Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Regulation Of Circadian Rhythm Cellular Protein Metabolic Process Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation	Chromatin Organization Positive Regulation Of Transcription, DNA-templated
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Migraine ( 27322543)	Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)
Interacting Genes		25 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RNF115 SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	6 interacting genes: FUS H3-4 POLR2A TOP3A UBC USP9X
Entrez ID		8239	81550
HPRD ID		02091	11625
Ensembl ID		ENSG00000124486	ENSG00000083544
Uniprot IDs		Q6P468 Q86X58 Q93008	A0A024QZE0 Q9H7E2
PDB IDs		5VBD 5WCH	1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T
Enriched GO Terms of Interacting Partners?
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