GAN and ATG16L1

Data Source:
BioGRID (protein complementation assay)

		GAN	ATG16L1
Description		gigaxonin	autophagy related 16 like 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Cytoskeleton Organization Protein Ubiquitination Post-translational Protein Modification	Autophagosome Assembly Protein Transport Macroautophagy Protein Phosphopantetheinylation Negative Stranded Viral RNA Replication
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		4 interacting genes: ATG16L1 MAP1B TBCB UBA1	15 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN NOD1 NOD2 OPTN RAB33A RAB33B SETD7 TRAF3IP3 ZFP36
Entrez ID		8139	55054
HPRD ID		05647	16498
Ensembl ID		ENSG00000261609	ENSG00000085978
Uniprot IDs		A0A0S2Z4W2 B3KTC3 Q9H2C0	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		2PPI 3HVE	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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