ATG16L1 and GAN

Data Source:
BioGRID (protein complementation assay)

		ATG16L1	GAN
Description		autophagy related 16 like 1	gigaxonin
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GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding	Molecular_function Protein Binding
	Biological Process	Autophagosome Assembly Protein Transport Macroautophagy Protein Phosphopantetheinylation Negative Stranded Viral RNA Replication	Cytoskeleton Organization Protein Ubiquitination Post-translational Protein Modification
Pathways		Macroautophagy Macroautophagy	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Crohn's disease
GWAS		Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)	Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN NOD1 NOD2 OPTN RAB33A RAB33B SETD7 TRAF3IP3 ZFP36	4 interacting genes: ATG16L1 MAP1B TBCB UBA1
Entrez ID		55054	8139
HPRD ID		16498	05647
Ensembl ID		ENSG00000085978	ENSG00000261609
Uniprot IDs		A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5	A0A0S2Z4W2 B3KTC3 Q9H2C0
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX	2PPI 3HVE
Enriched GO Terms of Interacting Partners?
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