ATG16L1 and TRAF3IP3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ATG16L1	TRAF3IP3
Description		autophagy related 16 like 1	TRAF3 interacting protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane	Golgi Membrane Mitochondrial Outer Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding	Protein Binding
	Biological Process	Autophagosome Assembly Protein Transport Macroautophagy Protein Phosphopantetheinylation Negative Stranded Viral RNA Replication
Pathways		Macroautophagy Macroautophagy
Drugs
Diseases		Crohn's disease
GWAS		Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)	Alopecia areata ( 25608926) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Orofacial clefts ( 33137956) Red blood cell count ( 32888494 27863252) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		15 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN NOD1 NOD2 OPTN RAB33A RAB33B SETD7 TRAF3IP3 ZFP36	47 interacting genes: ATG16L1 CBARP CCDC136 CCDC138 CCDC88B CCNC CDCA7L CEP68 CEP70 COQ9 CPLX4 CREB3L3 EBAG9 EMD EVI2B FAM209A FATE1 GOLGA6L9 GOLM2 GORAB GRAMD2A KASH5 KIR2DL3 KRT27 L3MBTL3 LIME1 LRRC25 MFF MINAR1 NDEL1 OSBPL3 PLEKHO1 PSTPIP1 RACGAP1 RIC3 RILPL1 SP100 STMN4 STX1A STX4 TFIP11 TMEM139 TRAF3 TRIM36 WAC ZNRD2 ZRANB1
Entrez ID		55054	80342
HPRD ID		16498	16305
Ensembl ID		ENSG00000085978	ENSG00000009790
Uniprot IDs		A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5	B1AJU2 B3KWQ9 Q9Y228
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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