SETD7 and ATG16L1

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SETD7	ATG16L1
Description		SET domain containing 7, histone lysine methyltransferase	autophagy related 16 like 1
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization	Autophagosome Assembly Protein Transport Macroautophagy Protein Phosphopantetheinylation Negative Stranded Viral RNA Replication
Pathways		PKMTs methylate histone lysines	Macroautophagy Macroautophagy
Drugs		S-adenosyl-L-homocysteine
Diseases			Crohn's disease
GWAS		Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)	Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		29 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21	15 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN NOD1 NOD2 OPTN RAB33A RAB33B SETD7 TRAF3IP3 ZFP36
Entrez ID		80854	55054
HPRD ID		16226	16498
Ensembl ID		ENSG00000145391	ENSG00000085978
Uniprot IDs		B5MCZ8 D6RJA0 Q8WTS6	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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