SETD7 and RIOK1

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		SETD7	RIOK1
Description		SET domain containing 7, histone lysine methyltransferase	RIO kinase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Nucleoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex
	Molecular Function	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Hydrolase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization	Protein Phosphorylation Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing
Pathways		PKMTs methylate histone lysines	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		S-adenosyl-L-homocysteine	Fostamatinib
Diseases
GWAS		Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)	Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		29 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21	7 interacting genes: APP CSNK2A1 FBXO6 KDM1A SETD7 WDR77 YWHAB
Entrez ID		80854	83732
HPRD ID		16226	17978
Ensembl ID		ENSG00000145391	ENSG00000124784
Uniprot IDs		B5MCZ8 D6RJA0 Q8WTS6	Q9BRS2
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT	4OTP 6G5I 6V0N
Enriched GO Terms of Interacting Partners?
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