CENPT and SNCB

Data Source:
HPRD (two hybrid)

		CENPT	SNCB
Description		centromere protein T	synuclein beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body	Cytoplasm Cytosol Inclusion Body Neuronal Cell Body Axon Terminus
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Transition Metal Ion Binding Cuprous Ion Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly	Chemical Synaptic Transmission Response To Metal Ion Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Neuron Death
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	MTF1 activates gene expression
Drugs
Diseases			Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: APP CENPW COPS5 DHX29 H3C1 PPCDC SNCB TCEA2	13 interacting genes: AKT1 APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 MORN4 PLK1 PLK3 SEPTIN4 SNCA
Entrez ID		80152	6620
HPRD ID		07811	03980
Ensembl ID		ENSG00000102901	ENSG00000074317
Uniprot IDs		B3KPB2 Q96BT3	G4Y815 G4Y816 Q16143
PDB IDs
Enriched GO Terms of Interacting Partners?
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