CENPT and CENPW

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		CENPT	CENPW
Description		centromere protein T	centromere protein W
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Nuclear Matrix
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Birth weight ( 31043758) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Cortical surface area (global PC1) ( 32198502) Cortical surface area (visual PC2) ( 32198502) Diastolic blood pressure ( 27841878) Feeling nervous ( 29500382) Food addiction ( 27106561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intracranial volume ( 22504418) Intraocular pressure ( 29617998) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 27182965 28196072) Menarche (age at onset) ( 27182965 25231870) Monobrow ( 27182965) Neurociticism ( 29500382) Neuroticism ( 29255261) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pulse pressure ( 27841878) QT interval ( 29213071) Subcortical brain region volumes ( 25607358) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 1 diabetes ( 30659077 30572963) Type 2 diabetes ( 30297969 32499647 28869590)
Interacting Genes		8 interacting genes: APP CENPW COPS5 DHX29 H3C1 PPCDC SNCB TCEA2	6 interacting genes: BTRC CENPB CENPT CUL1 H3C1 NPM1
Entrez ID		80152	387103
HPRD ID		07811	16660
Ensembl ID		ENSG00000102901	ENSG00000203760
Uniprot IDs		B3KPB2 Q96BT3	A0A0A0MRK5 Q5EE01
PDB IDs
Enriched GO Terms of Interacting Partners?
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