CENPT and PPCDC

Data Source:
HPRD (two hybrid)

		CENPT	PPCDC
Description		centromere protein T	phosphopantothenoylcysteine decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body	Cytosol Phosphopantothenoylcysteine Decarboxylase Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Phosphopantothenoylcysteine Decarboxylase Activity Protein Binding FMN Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly	Coenzyme A Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Coenzyme A biosynthesis
Drugs			Flavin mononucleotide Pantothenoylaminoethenethiol
Diseases
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Apolipoprotein A1 levels ( 32203549) Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707) Coffee consumption (cups per day) ( 31837886) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 26502338) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP CENPW COPS5 DHX29 H3C1 PPCDC SNCB TCEA2	13 interacting genes: CENPT DBI DDIT4L FOXR1 NAA80 NTAQ1 PLEKHF2 PPIG PSMA1 SREK1IP1 TXN2 UBE2I ZNF232
Entrez ID		80152	60490
HPRD ID		07811	14377
Ensembl ID		ENSG00000102901	ENSG00000138621
Uniprot IDs		B3KPB2 Q96BT3	H3BQB0 H3BRQ0 H3BSE3 H3BU63 Q96CD2
PDB IDs			1QZU
Enriched GO Terms of Interacting Partners?
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