GRHL2 and PAX5

Data Source:
BioGRID (two hybrid)

		GRHL2	PAX5
Description		grainyhead like transcription factor 2	paired box 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell-cell Junction Membrane	Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Cell Adhesion Brain Development Cell Population Proliferation Epidermis Development Neural Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Regulation Of DNA Methylation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Telomerase Activity Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Anterior Neural Tube Closure Bicellular Tight Junction Assembly Epithelium Migration	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation
Pathways			RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases			Lymphoplasmacytic lymphoma
GWAS		Bronchopulmonary dysplasia ( 23897914) Rheumatoid arthritis ( 30423114 24390342)	Adult body size ( 32376654) Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		6 interacting genes: APP GRHL3 LMO4 PAX5 PAX6 PIAS2	55 interacting genes: ACOT12 BCAS2 C1orf109 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 EP300 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5
Entrez ID		79977	5079
HPRD ID		10545	01334
Ensembl ID		ENSG00000083307	ENSG00000196092
Uniprot IDs		B4DL28 Q6ISB3	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs		5MR7	1K78 1MDM
Enriched GO Terms of Interacting Partners?
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