PAX5 and HMGB3

Data Source:
BioGRID (two hybrid)

		PAX5	HMGB3
Description		paired box 5	high mobility group box 3
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Four-way Junction DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding DNA Binding, Bending
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation	DNA Recombination Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development DNA Geometric Change Innate Immune Response Negative Regulation Of B Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		55 interacting genes: ACOT12 BCAS2 C1orf109 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 EP300 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	7 interacting genes: HMGA1 MEOX1 MEOX2 PAX5 PAX6 SDCBP TERF2IP
Entrez ID		5079	3149
HPRD ID		01334	02181
Ensembl ID		ENSG00000196092	ENSG00000029993
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	O15347
PDB IDs		1K78 1MDM	2EQZ 2YQI
Enriched GO Terms of Interacting Partners?
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