GRHL2 and GRHL3

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		GRHL2	GRHL3
Description		grainyhead like transcription factor 2	grainyhead like transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell-cell Junction Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Cell Adhesion Brain Development Cell Population Proliferation Epidermis Development Neural Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Regulation Of DNA Methylation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Telomerase Activity Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Anterior Neural Tube Closure Bicellular Tight Junction Assembly Epithelium Migration	Establishment Of Planar Polarity Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Eyelid Development In Camera-type Eye Establishment Of Skin Barrier Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Rheumatoid arthritis ( 30423114 24390342)	Cleft palate ( 28054174 27018472) Fasting blood insulin (BMI interaction) ( 22581228) Male-pattern baldness ( 28196072) Response to interferon beta in multiple sclerosis ( 26644207)
Interacting Genes		6 interacting genes: APP GRHL3 LMO4 PAX5 PAX6 PIAS2	8 interacting genes: EAF1 ENKD1 GRHL1 GRHL2 PRMT1 PRMT5 PRMT6 RIPPLY1
Entrez ID		79977	57822
HPRD ID		10545	12210
Ensembl ID		ENSG00000083307	ENSG00000158055
Uniprot IDs		B4DL28 Q6ISB3	Q8TE85
PDB IDs		5MR7
Enriched GO Terms of Interacting Partners?
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