ERMP1 and BSCL2

Data Source:
BioGRID (two hybrid)

		ERMP1	BSCL2
Description		endoplasmic reticulum metallopeptidase 1	BSCL2 lipid droplet biogenesis associated, seipin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Metallopeptidase Activity Metal Ion Binding	Protein Binding Phospholipid Binding
	Biological Process	Proteolysis Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		Asthma ( 31959851 31619474) Blond vs. brown/black hair color ( 30531825) Waist-hip ratio ( 28552196)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: AQP2 AQP6 ATP1B4 BCL2L13 BSCL2 CD200R1 CLDN5 CLDN7 CLDN9 CLEC2D CREB3L1 ERVFRD-1 FAM209A FNDC9 GJA8 GPR42 GPRC5D HHLA2 HIBADH IER3IP1 IFNGR2 KCNN3 KLRC1 LYPD5 MR1 PDCD1LG2 PEX12 RHCG SLC13A4 SLC22A23 SLC23A2 SLC7A14 SPAG4 SSMEM1 TMEM237 TMEM45A TMEM80	38 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 FAM20B GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 STRIT1 TEX37 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3
Entrez ID		79956	26580
HPRD ID		17227	05858
Ensembl ID		ENSG00000099219	ENSG00000168000
Uniprot IDs		Q6ZMD3 Q7Z2K6	A0A024R540 A0A024R549 Q96G97
PDB IDs			6DS5
Enriched GO Terms of Interacting Partners?
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