GEMIN7 and STRAP

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology)
HPRD (in vitro)

		GEMIN7	STRAP
Description		gem nuclear organelle associated protein 7	serine/threonine kinase receptor associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies Sm-like Protein Family Complex	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex
	Molecular Function	Protein Binding	RNA Binding Signaling Receptor Binding Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Import Into Nucleus	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal SnRNP Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		snRNP Assembly	Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		20 interacting genes: ADD1 CEP126 EDRF1 FEZ1 GEMIN6 GOLM1 KAT5 RN7SL1 RNU1-1 RNU2-1 RPLP1 SHC1 SMN1 SNRPB SNRPD2 SNRPD3 SNRPE STRAP TAOK1 TUBA1A	27 interacting genes: CHEK2 GEMIN6 GEMIN7 MAP1B MTRES1 NXF1 PBLD PDPK1 PTEN RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO2 SUMO4 SZRD1 TGFBR1 TGFBR2
Entrez ID		79760	11171
HPRD ID		07600	05816
Ensembl ID		ENSG00000142252	ENSG00000023734
Uniprot IDs		Q9H840	B0AZV0 Q9Y3F4
PDB IDs		1Y96
Enriched GO Terms of Interacting Partners?
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