STRAP and CHEK2

Data Source:
BioGRID (enzymatic study)

		STRAP	CHEK2
Description		serine/threonine kinase receptor associated protein	checkpoint kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body
	Molecular Function	RNA Binding Signaling Receptor Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal SnRNP Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Peptidyl-serine Phosphorylation Cellular Response To Drug Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Negative Regulation Of Cell Cycle Arrest Cellular Response To Gamma Radiation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			XL844 Enzastaurin Fostamatinib
Diseases			Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS			Breast cancer ( 29059683 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 32888494 28957414) Vertical cup-disc ratio ( 20548946 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		27 interacting genes: CHEK2 GEMIN6 GEMIN7 MAP1B MTRES1 NXF1 PBLD PDPK1 PTEN RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO2 SUMO4 SZRD1 TGFBR1 TGFBR2	80 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL
Entrez ID		11171	11200
HPRD ID		05816	05084
Ensembl ID		ENSG00000023734	ENSG00000183765
Uniprot IDs		B0AZV0 Q9Y3F4	O96017
PDB IDs			1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?
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