CACNB4 and CACNA1A

Data Source:
HPRD (in vitro)

		CACNB4	CACNA1A
Description		calcium voltage-gated channel auxiliary subunit beta 4	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		Presynaptic depolarization and calcium channel opening NCAM1 interactions	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil	Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone	Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		12 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		785	773
HPRD ID		09057	03004
Ensembl ID		ENSG00000182389	ENSG00000141837
Uniprot IDs		A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		2D46	3BXK
Enriched GO Terms of Interacting Partners?
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